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Rs2802292

rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts. Fuku N et al. 2016: Maturitas: 27694344: Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. Willcox BJ et al. 201 [ PMID 25208626] Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes [ PMID 27071935] The FoxO3 gene and cause-specific mortalit

rs2802292 RefSNP Report - dbSNP - NCB

Of note, among non-coding SNPs the rs2802292 minor allele (G), located at intron 2, has been shown to be strongly associated with long-lived subjects in all human populations tested (13)(14)(15. It focuses on a SNP in the FoxO3 gene (rs2802292) which has been previously associated with longevity - is it overrepresented in centenarians [2], as discussed here, and summarized as: [T]he odds ratio for reaching 100 years of age for rs2802292(G;G) vs (T;T) carriers was 2.75 (p = 0.00009; adjusted p = 0.00135)

rs2802292 Where else can I learn more about rs2802292? GeneCards. GeneCards is a searchable, integrated database of human genes that provides comprehensive, updated, and user-friendly information on all known and predicted human genes.. Heat-shock factor 1 (HSF1) activates due to stress from heat, and HSF, in turn, interconnects with FOXO3 - specifically through a difference in the FOXO3 formation in the rs2802292 G allele. While there aren't specific human studies on this yet, people with the rs2802292 G allele may benefit more from heat stress such as using a sauna Research Design and Methods: rs2802292 was genotyped in a phenotypically well-characterized population of young and elderly twins (n = 190) and in the population-based Inter99 cohort (n = 5768)

Association between FOXO3A gene polymorphisms and human

Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional long Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes

rs2802292 - SNPedi

I have G/G on FOXO3 rs2802292 108908518 is this the same thing saying there is a more likely chance that I'll live longer here?That's what it looks like but the paragraph below is confusing me a bit. 23andMe blog longevity rs2802288(A) increased the odds of living to 100 by 1.5x. rs2802288 is located very close to rs2802292 which was previously reported to have a similar effect Interestingly, the FOXO3A rs2802292 G-allele was shown to be associated with longevity, reduced risk of aging-related diseases and increased expression of FoxO3A mRNA Objectives Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting In the Willcox study, the investigated genetic variations (rs2802292, rs2764264, and rs13217795) within the FOXO3A gene were significantly associated with longevity in male centenarians. We validated the association of FOXO3A polymorphisms with extreme longevity in males from the Southern Italian Centenarian Study

rs2802292 SelfDecode Genome Analysi

Interestingly, the FOXO3A rs2802292 G-allele was shown to be associated with longevity, reduced risk of aging-related diseases and increased expression of FoxO3A mRNA. Methods: We typed rs2802292 in 150 HPS unrelated patients and characterized the expression of FoxO3A by quantitative PCR and immunoblot analysis in human intestinal cell lines Rs2802288 is located very close to rs2802292, which was one of the SNPs found in the September 2008 report by Willcox et al on Japanese men living in Hawaii. In that study, men with an A at rs2802292 had 1.91 times odds of living to 95 or older compared to those with two Cs; two As increased the odds by 2.75 times The rs2802292 minor G-allele has a key role in the stress resistance phenotype of human cells. (A-F) Experiments performed on human primary dermal fibroblasts homozygous for the rs2802292 G-allele. So far, three functional longevity-associated variants have been identified at the FOXO3 locus (rs2802292, rs12206094, and rs4946935). For all of them, an allele-specific response to cellular.

The longevity SNP rs2802292 uncovered: HSF1 activates

  1. rs2802292 G-allele displayed significant correlation with increased basal expression of FoxO3A mRNA in muscle biopsies of twins, suggesting that the second intron of the FOXO3A locus, which contains the rs2802292 SNP, may act as a regulatory sequence [15]. These data suggest that the rs2802292 G-allele coul
  2. FOXO3a is also involved in protection from oxidative stress by increasing antioxidants such as catalase and MnSOD (SOD2). This gene is associated with health and longevity . FOXO3a is important for the mitochondria, insulin resistance, apoptosis, tumor suppression, muscle regeneration via stem cells and anti-oxidant function (such as catalase and MnSOD) ()
  3. ally significant differences for block 1 betwee
  4. morphism rs2802292 has enhancer functions, and that the rs2802292 G-allele creates a novel HSE bind-ing site for HSF1, which induces FOXO3 expres-sion in response to diverse stress stimuli. At the molecular level, HSF1 mediates the occurrence of a promoter-enhancer interaction at FOXO3locus in-volving the 5 UTR and the rs2802292 region. Thes

The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins. 2011: 3: 10.1210/jc.2010-0881: Karina Banasi Moreover, our study showed no association between rs2153960, rs7762395 or rs13220810 polymorphisms and longevity. In conclusion, this meta-analysis indicates a significant association of five FOXO3A gene polymorphisms with longevity, with the effects of rs2802292 and rs2764264 being male-specific These data suggest that the rs2802292 G-allele could enhance the well-known metabolic and anti-aging activities of FOXO3A by increasing gene expression. Indeed, FoxO3A plays a role in proliferation/arrest, survival/death, metabolism and autophagy, and has been implicated in tumor suppression, regulation of energy metabolism and development in a number of tissues [] Objective: The minor G allele of FOXO3A rs2802292 has been associated with longevity. We aimed to investigate whether a phenotype related to healthy metabolic aging could be identified in individuals carrying the longevity-associated FOXO3A rs2802292 G allele. Research Design and Methods: rs2802292 was genotyped in a phenotypically well-characterized population of young and elderly twins (n. Interestingly, the FOXO3A rs2802292 G-allele was shown to be associated with longevity, reduced risk of aging-related diseases and increased expression of FoxO3A mRNA. METHODS: We typed rs2802292 in 150 HPS unrelated patients and characterized the expression of FoxO3A by quantitative PCR and immunoblot analysis in human intestinal cell lines

Stratified analysis of the rs2802292 polymorphism in females included two studies (1354 cases and 739 controls) and was conducted using a random-effect model. There was no significant association of the rs2802292 polymorphism with female longevity (OR = 1.16, 95% CI = 0.86-1.57, P = 0.34). The Forest plot is shown in [Figure 3] A recent study by the University of Hawaii concluded that the G allele of the FOXO3a SNP rs2802292 (genotypes GG and GT) is associated with shorter stature as well as longevity. They are just ever so slight alterations in the genetic fabric yet have considerable impact Endpoint Genotyping. Detect known variants by qPCR. Identify known genetic mutations quickly and easily with ready-to-use LightCycler ® Master Mixes designed for endpoint genotyping, the most commonly used genotyping method. These mixes will provide you with a robust and reliable testing method for SNPs by endpoint analysis with hydrolysis probes rs2802292 in the FOXO3 gene is associated with centenarian Japanese men. rs1935949 has been coorelated in women rs3758391 in the SIRT1 gene is associated with cognitive health longevity rs5882 in the CETP gene is associated with cognitive health longevit For this project, neflamapimod and placebo will be provided free of charge by the EIP company (www.eippharma.com). Neflamapimod is currently tested in 2 clinical trials in AD, one in Europe (The Netherlands) and one in the USA (clinical trials.gov/VX-745)

Patients characteristics according to the presence of

FOXO3A genotype is strongly associated with human longevity Bradley J. Willcox*†‡§, Timothy A. Donlon*¶, Qimei He*, Randi Chen*†, John S. Grove*¶, Katsuhiko. In conclusion, the G allele of the FOXO3 SNP rs2802292 has a major effect on mortality, principally through reduction in CHD risk, independent of known major risk factors. The findings support research on FOXO3 as a target for therapeutic intervention in healthy aging 23andMe blog longevity rs2802288(A) increased the odds of living to 100 by 1.5x. rs2802288 is located very close to rs2802292 which was previously reported to have a similar effect. 1 2 comment Figure Lengend Snippet: HSF1 binds to the genomic rs2802292 SNP region in cells homozygous for the rs2802292 G-allele and induces the expression of FOXO3 in a stress-dependent manner

Journal: Nucleic Acids Research Article Title: The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer doi: 10.1093/nar/gky331 Figure Lengend Snippet: The rs2802292 locus has enhancer properties and the presence of the G-allele creates a unique binding site for HSF1, which is required for transcriptional activation Abstract. The HSF and FOXO families of transcription factors play evolutionarily conserved roles in stress resistance and lifespan. In humans, the rs2802292 G-allele at FOXO3 locus has been associated with longevity in all human populations tested; moreover, its copy number correlated with reduced frequency of age-related diseases in centenarians

rs2802292(T;T) - SNPedi

The FOXO3 SNP rs2802292 resides in intron 1 of FOXO3 that encodes for a member of the Forkhead Box O transcription factor family. This SNP and its linked SNPs have been shown to associate with allelic differences in longevity and insulin sensitivity. 14-19 For example, centenarians from seven independent cohorts were significantly enriched for. Max Magnitude 2.4 23andMe blog longevity rs2802288 (A) increased the odds of living to 100 by 1.5x. rs2802288 is located very close to rs2802292 which was previously reported to have a similar effect. [ PMID 18978678] Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts

Replication of rs2802292 with EHT was attempted in Japanese SONIC study subjects and of each SNP in a meta-analysis of genome-wide association studies of BP in individuals of European ancestry. RESULTS: In Americans of Japanese ancestry, women homozygous for the longevity-associated (minor) allele of each FOXO3 SNP had 6mm Hg lower systolic BP. The G allele of the FOXO3 SNP rs2802292 has a strong, consistently replicated protective association with longevity. We investigated the effect of FOXO3 genotype on coronary heart disease (CHD) mortality - a major cause of mortality worldwide. We genotyped DNA collected in 1991-93, at Exam 4 of the Honolulu Heart Program (HHP), from 3,584 American males of Japanese ancestry aged 71-93 years Significant genetic predisposition of rs2802292 and haplotype AGTG (5) to ] and 1.931 [1.119-3.33], respectively were found, while rs1536057 and rs1935952 displayed an opposite effect in the disease , respectively) (Fig. 1B).The finding that none of the common SNPs evaluated are located in the coding region does not exclude the polymorphisms.

The human forkhead box O3A gene ( FOXO3A ) encodes an evolutionarily conserved key regulator of the insulin-IGF1 signaling pathway that is known to influence metabolism and lifespan in model organisms. A recent study described 3 SNPs in the FOXO3A gene that were statistically significantly associated with longevity in a discovery sample of long-lived men of Japanese ancestry [Willcox et al. FOXO3A polymorphisms (rs2802292, rs2764264, and rs13217795) were analyzed for longevity associations in 281 long-lived men (age range 90-108 years) and 195 controls (age range 18-48 years) from the Southern Italian Centenarian Study With regards to epistasis, we found a FOXOA3 rs2802292 T-allele-dependent association of fibronectin type III domain-containing 5 (FDNC5) rs16835198 with EL, that is, among individuals with the rs16835198 GG genotype, the frequency of carriers of the FOXOA3 rs2802292 T-allele was significantly higher in cases than in controls (P < 0.05; Table 2)

The FOXO3A rs2802292 G-allele associates with improved

  1. Below, I've plotted the frequency of the early-dying version of the most strongly associated variant in FOXO3A, rs2802292, for individuals in five groups (three young and two old) scattered.
  2. Rs2802292, rs10457180, and rs12206094 are located in 5' UTR variant, intron variant, intron variant (upstream variant 2KB) of FOXO3 gene respectively and χ 2 tests revealed that all SNPs were in the balance of Hardy-Weinberg (P >0.05)
  3. The G allele of the FOXO3 single nucleotide polymorphism (SNP) rs2802292 exhibits a consistently replicated genetic association with longevity in multiple populations worldwide
  4. e
  5. $\begingroup$ Thank you for the welcome:I think my confusion is based on visualizing SNPs as single base pair substitution in the gene: I thought SNPs can vary by basepair but not in total number - here 8 vs 2. In the example rs2802292 is possessed by both individuals but with #1 carrying (G;T), and #2 carrying ( T;T) SNPs for rs2802292 which makes sense
Association between longevity and FOXO3A SNP genotypeGG genotype is associated with increased expression of

rs2802292 polymorphism in the FOXO3A gene and exceptional

  1. Moreover, our study showed no association between rs2153960, rs7762395 or rs13220810 polymorphisms and longevity.ConclusionsIn conclusion, this meta-analysis indicates a significant association of five FOX03A gene polymorphisms with longevity, with the effects of rs2802292 and rs2764264 being male-specific
  2. ally significant differences in allele frequencies were found for the males for five SNPs (rs12206094, rs13220810, rs2802292, rs3800231, and rs9486902), while with respect to genotype frequencies, no
  3. Explore your genetic data for free in a modern search-like interface. Investigate links to over 2000 diseases and see how you compare to the overall population. Nutrition and fitness reports included
  4. A recent work showed that the 90-bp sequence around rs2802292 has an enhancer function. Indeed, the rs2802292 G-allele creates a unique HSE DNA-binding site for HSF1, inducing the expression of FOXO3a in response to different types of cellular stress (nutrient, genotoxic, and oxidative stress)
  5. Life expectancy is up, people are living longer than ever before. However, living to the age of 100 remains a remarkable and somewhat rare feat. What are the odds that you'll live to age 100
  6. or n=10, heterozygous n=21 and major n=11 and (C) rs12206094 SNP carrier:

(PDF) Characterization of the rs2802292 SNP identifies

  1. As well, genotype and allele frequencies for SNPs rs7412 and rs429358 in APOE, and rs2802292 in FOXO3 were compared to the frequencies in the original collection of Super-Seniors and mid-life controls. Of the 480 Super-Seniors recruited from 2004 to 2007, 13 were alive, contactable, and consented to re-interview (mean age = 100.1 ± 3.3)
  2. rs13217795 (p 0.0006), and rs2802292 (p 0.0001).22 The aim of our study was to support the potential role of FOXO3A as a key component that influences longevity with a case-control study. We screened 480 long-living cases (281 males and 199 females) and 335 young controls (195 males, 140 females) from an isolated and homogeneous pop
  3. Residential greenness is an important environmental factor that is strongly associated with mortality. To our knowledge, there was no previous study on the gene-environment interaction analysis between residential greenness and forkhead box O (FOXO) gene, a candidate longevity gene.Our sample consisted of 3179 participants aged 65 and older from the Chinese Longitudinal Healthy Longevity Survey
  4. or) allele of each FOXO3 SNP had 6mm Hg lower systolic BP.

SNP, rs2802292, or were homozygous for the major (T) allele. These curves were determined using a Cox proportional hazard model adding an interaction term of FOXO3 with CMD. Only in CMD subjects was the G allele associated with greater lifespan than TT (p = 0.0002). Subjects without a CMD had the longest lifespans Among these five SNPs, rs2802292 and rs2764264 polymorphisms were observed in males only. The combined effect of FOXO3A and APOE on long-term living has also been reported [ 2 , 16 , 82 ]. Additionally, an increase in the activity of daily life and decrease in the risk of bone fracture in individuals with FOXO3A SNPs were found in long-lived. A genetic test can identify 77% of people predisposed to live to 100 and beyond. Some 15% of people of European descent have more than a 50% chance of exceptional longevity Notably, combining multifactor dimensionality reduction and logistic regression, we identified a significant 3-factor interaction model (rs2802288, rs2802292 and moderate physical activity) associated with lower FH risk. However, not all of the findings were replicated in the two middle-aged cohorts

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. Nucleic Acids Res May 4 2018 [PMID: 29733381] Reviews for DNA/RNA Damage Kit (KA0784) (0 FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity, oxidative stress status, and DNA integrity level in oldest-old individuals from southeastern Brazil. Materials and Methods Subjects This is an observational and analytical study of 452 unrelated individuals. The sample of long-lived. FOXO3 SNP rs2802292-HSF1 axis in response to different types of cellular stresses (nutrient, genotoxic, and oxidative stress) and reports that the rs2802292 SNP takes part in a pro-longevity haplotype. Considering the significant role of this SNP in cellular stress response and homeostasis, we believe it is important to mention this mechanism

FoxO3 Allele Associated with Reduced All-Cause Mortality

However, the meta-analysis of the CHARGE discovery results with published results for the FOXO3 variant rs2802292 revealed that the G allele was associated with increased odds of longevity at the genome-wide significance level (OR=1.17, P=1.9x10-10). Approac The LightCycler ® 480 Genotyping Master is a hot start reaction mix for PCR. The supplied enzyme contains a 5'-3'-exo-minus, N-terminal deletion of thermostable recombinant Taq DNA polymerase that is inactive at room temperature due to a chemical modification, and becomes activated during a 10-minute incubation at +95°C Banasik, K. et al. The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins. J. Clin. Endocrinol rs2802292, rs3800231, rs479744, and rs7762395 (see Experimental procedures). None of the initial findings could be formally replicated. However, all of the effect estimates observed in the Replication sample were in the same direction, although generally attenuated, as compared to the Discovery sample (compare Table 3A to B, and Table 3D to E)

rs2802292 - Livewell

rs2802292. G. If there is a enhancement related mutation not listed here that you would like to see added, please contact us with the details and we will work to add it. ADDRESS. Address: E. Ramos St., Dewey AZ 86327 Email: somkardevelopers@gmail.com. I've got FOXO3 rs2802292 g/g, rs1935949 t/t and CETP rs5882 g/g. I'm hoping and praying those help me out. My last cholesterol numbers (that should've been fasting but weren't) were: HDL 59 LDL 120 Triglycerides 53 They aren't crazy good but doctor didn't seem concerned. Now that I know I have apoe 3/4, I'm concerned that my ldl is too high rs2802292 - GG 2. rs1935949 - AG 1. rs3758391 - CC 0. rs5882 - AA 0. rs1042522 - CC 2. rs1800795 - CG 1. rs2811712 - AA 0. rs34516635 - GG 0. rs2542052 - AA 0. rs3803304 - CC 2 final score: 8 And dementia: rs190982 - AG 1. rs2718058 - AG Apart from its well-known ancestry DNA test, 23andMe also offers a health-related report informing you of your genetic predispositions for numerous diseases and conditions as well as your carrier status for some of the most dangerous genetic mutations. Read our detailed guide for a complete list of diseases 23andMe screens for with every test

Longevity and Genetics: FOXO3, CETP, IGF1, and more

Here we describe the role of FOXO3 and its single-nucleotide polymorphisms (SNPs) in healthy aging, with a focus on the enhancer region encompassing the SNP rs2802292, which upregulates FOXO3 expression and can promote the activity of the aging hub in response to different stress stimuli. FOXO3 protective effect on lifespan may be due to the. Lead author and CHeBA PhD student Mary Revelas said polymorphisms, or variations in the genetic code, of five genes were identified as exceptional longevity variants in studies of people aged 85 and over versus controls: ACE rs4340, APOE ε2/3/4, FOXO3A rs2802292, KLOTHO KL-VS and IL6 rs1800795 Italian Centenarian Study. Particularly, rs2802288, a proxy of rs2802292, showed the best allelic association (MAF=0.49, p=0.003, OR=1.51, 95% CI: 1.15-1.98). Furthermore we undertook a meta-analysis in order to explore the significance of rs2802292 association with longevity by combining the association results of th

FOXO3A rs2802292 G-Allele Associates with Improved

Results. We found a FOXOA3 rs2802292 T-allele-dependent association of fibronectin type III domain-containing 5 (FDNC5) rs16835198 with EL: the frequency of carriers of the FOXOA3 rs2802292 T-allele among individuals with the rs16835198 GG genotype was significantly higher in cases than in controls (P < 0.05).On the other hand, among non-carriers of the APOE 'risk' ε4-allele, the. Altogether, the molecular mechanisms described here may help establish whether the rs2802292 SNP can be taken advantage of in predictive medicine and define the potential of targeting FOXO3 for age-related diseases. A Consistent Transcriptomic Signature of Cellular Senescence https:.

VarSome.com Premium is a subscription service allowing you to access additional 3rd party annotation data resources and features without any delays rs429358 in APOE, and rs2802292 in FOXO3 were compared to the frequencies in the original Phase 1 Super-Seniors and mid-life controls. Genotypes for these select variants were extracted from data previously de-scribed [15]. Statistical analysis was done using R 3.2.2 and JMP 13. Results In 2010, we mailed 480 Super-Seniors and an additiona The FOXO3A rs2802292 allele is another variant found associated with exceptional longevity across popu-lations [20,22-24]. Nevertheless, this polymorphism has no apparent impact on the functions of FOXO3A and it is not in LD with functional variants. However, FOXO3A is part of a pathway associated with longevity: IGF1/ PI3K/PDK1/AKT/FOXO opinions on privacy of genomic information! Another interesting SNP (rs2802292) is in the region chr6:108,587,295-108,587,335. 12. [Just to think about] Is there anything in his genome that Dr. Watson should be worried about? Precision medicine researchers and companies can use computers to analyze al rs2802292 . is. strongest • 36% in likelihood of living to ≥ 95 years • G. allele creates binding site for HSF1 . resilience to stress longevity • inflammation, no telomere attrition, risk of death from coronary heart disease. FOXO3. Willcox . et al. PNAS. 2008, Aging Cell . 2016; Donlon . et al. Aging Cell . 2017 . Grossi . et al. NAR.

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